Intractable Epilepsy: Definition and Neurobiology

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Intractable epilepsy: definition and neurobiology.

Approximately 20% ef individuals with a diagnosis of epilepsy have seizures that are not adequately controlled by antiepileptic drugs, In some of these, the patients fail to respond because their paroxysmal events are not epileptic; in others, an incorrect treatment plan has been prescribed, either due to misdiagnosis of seizure type or misinformation about appropriate therapy; and in still oth...

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Definition of intractable epilepsy.

Defining intractable epilepsy is essential not only to identify up to 40% of patients refractory to pharmacological management, but also to facilitate selection and comparison of such patients for research purposes. The ideal definition still eludes us. Multiple factors including number of antiepileptic drug (AED) failures, seizure frequency and duration of unresponsiveness, etiology, and epile...

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Hemispherotomy for intractable epilepsy.

CONTEXT Hemispherotomy is a surgical procedure for hemispheric disconnection. It is a technically demanding surgery. Our experience is presented here. AIMS To validate and compare the two techniques for hemispherotomy performed in patients with intractable epilepsies. SETTINGS AND DESIGN A retrospective study 2001-March 2007: Nineteen cases of hemispherotomies from a total of 462 cases oper...

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Intractable Epilepsy in Children

Corresponding Author: J. Akhondian MD Ghaem Medical Center,Mashad,Iran Tel: +98 511 8012469 Fax: +98 511 8417451 Email: [email protected] Abstract Objective Epilepsy is a common disorder affecting approximately 1% of the population. It is estimated that about 2030% of the patients become refractory to proper medical therapies. Such cases are often termed intractable. Intractable epilepsy (I...

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intractable epilepsy in children

objective epilepsy is a common disorder affecting approximately 1% of the population. it is estimated that about 20- 30% of the patients become refractory to proper medical therapies. such cases are often termed intractable. intractable epilepsy (ie) is a serious condition in children, leading to significant impairment in quality of life, as well as behavioral and psychiatric problems. in this ...

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ژورنال

عنوان ژورنال: Epilepsia

سال: 2008

ISSN: 0013-9580,1528-1167

DOI: 10.1046/j.1528-1157.42.s6.10.x